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Article

Novel GRN Mutations in Patients with Corticobasal Syndrome.

Scientific reports - 10 Mar 2016

Taghdiri Foad, Sato Christine, Ghani Mahdi, Moreno Danielle, Rogaeva Ekaterina, Tartaglia Maria Carmela

Abstract excerpt

Loss-of-function GRN mutations lead to GRN haploinsufficiency and consequently neurodegeneration with significant heterogeneity in clinical presentation of various syndromes. The aim of this study was to investigate the genetics and clinical features of patients with GRN-related frontotemporal lobar degeneration (FTLD) syndromes. We performed mutation analysis of GRN in 45 unrelated Canadian patients with a broad...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26961809
DOI: 10.1038/srep22913
PMCID: PMC4785496

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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