Article
Detection of tumor epidermal growth factor receptor pathway dependence by serum mass spectrometry in cancer patients.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2010
Chung Christine H, Seeley Erin H, Roder Heinrich, Grigorieva Julia, Tsypin Maxim, Roder Joanna, Burtness Barbara A, Argiris Athanassios, Forastiere Arlene A, Gilbert Jill, Murphy Barbara, Caprioli Richard M, Carbone David P, Cohen Ezra E W
Abstract excerpt
BACKGROUND: We hypothesized that a serum proteomic profile predictive of survival benefit in non-small cell lung cancer patients treated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) reflects tumor EGFR dependency regardless of site of origin or class of therapeutic agent. METHODS: Pretreatment serum or plasma from 230 patients treated with cetuximab, EGFR-TKIs, or chemotherapy for...
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