Article
Classification of Epidermal Growth Factor Receptor Gene Mutation Status Using Serum Proteomic Profiling Predicts Tumor Response in Patients with Stage IIIB or IV Non-Small-Cell Lung Cancer.
PloS one - 1 Jan 2015
Yang Lin, Tang Chuanhao, Xu Bin, Wang Weixia, Li Jianjie, Li Xiaoyan, Qin Haifeng, Gao Hongjun, He Kun, Song Santai, Liu Xiaoqing
Abstract excerpt
OBJECTIVES: Epidermal growth factor receptor (EGFR) gene mutations in tumors predict tumor response to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in non-small-cell lung cancer (NSCLC). However, obtaining tumor tissue for mutation analysis is challenging. Here, we aimed to detect serum peptides/proteins associated with EGFR gene mutation status, and test whether a classification algorithm based on serum proteomic...
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