Article
Mutation and polymorphism of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease (CJD).
American journal of human genetics - 1 Oct 1993
Gabizon R, Rosenmann H, Meiner Z, Kahana I, Kahana E, Shugart Y, Ott J, Prusiner S B
Abstract excerpt
The inherited prion diseases are neurodegenerative disorders which are not only genetic but also transmissible. More than a dozen mutations in the prion protein gene that result in nonconservative amino acid substitutions segregate with the inherited prion diseases including familial Creutzfeldt-...
Topics
- Age of Onset
- Alleles
- Base Sequence
- Creutzfeldt-Jakob Syndrome
- DNA Mutational Analysis
- DNA, Single-Stranded
- Genetic Linkage
- Genotype
- Homozygote
- Humans
- Jews
- Libya
- Molecular Sequence Data
- Mutation
- Nerve Tissue Proteins