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Article

Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components.

The Journal of clinical endocrinology and metabolism - 1 Mar 2010

Phillips Catherine M, Goumidi Louisa, Bertrais Sandrine, Ferguson Jane F, Field Martyn R, Kelly Enda D, Mehegan John, Peloso Gina M, Cupples L Adrienne, Shen Jian, Ordovas Jose M, McManus Ross, Hercberg Serge, Portugal Henri, Lairon Denis, Planells Richard, Roche Helen M

Abstract excerpt

CONTEXT: Cytokine polymorphisms and dietary fat composition may influence the risk of the metabolic syndrome (MetS). OBJECTIVE: The objective of the study was to determine the relationship between lymphotoxin-alpha (LTA), TNF-alpha, and IL-6 gene polymorphisms with MetS risk and investigate whether plasma fatty acid composition, a biomarker of dietary fat intake, modulated these associations. DESIGN:...

Topics

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C-Reactive Protein
Dietary Fats
Fatty Acids
Interleukin-6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphotoxin-alpha

Metabolic Syndrome

Regression Analysis

Waist Circumference

Source

Identifiers

PMID: 20080841
DOI: 10.1210/jc.2009-1081

Genes

LTA
TNF
MAX

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