A cloned gene encoding phosphatidylserine decarboxylase complements the phosphatidylserine biosynthetic defect of a Chinese hamster ovary cell mutant.

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Article

A cloned gene encoding phosphatidylserine decarboxylase complements the phosphatidylserine biosynthetic defect of a Chinese hamster ovary cell mutant.

The Journal of biological chemistry - 5 Apr 1991

Kuge O, Nishijima M, Akamatsu Y

Abstract excerpt

A phosphatidylserine-auxotrophic mutant of cultured Chinese hamster ovary cells, PSA-3, manifests a defect in phosphatidylserine synthase I activity (Kuge, O., Nishijima, M., and Akamatsu, Y. (1986) J. Biol. Chem. 261, 5790-5794). We cloned a Chinese hamster gene, designated pssC, which was able to transform the PSA-3 cell line to a phosphatidylserine prototroph. The resultant transformant contained...

Topics

Amino Acid Sequence
Animals
Base Sequence
Carboxy-Lyases
Cell Line
Cloning, Molecular
Cricetinae
Cricetulus
Escherichia coli
Gene Expression Regulation, Bacterial
Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Bacterial

Genes, Fungal

Molecular Sequence Data

Mutation

Phosphatidylethanolamines

Phosphatidylserines

Plasmids

Source

Open in PubMed

Identifiers

PMID: 2007589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2007589-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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