Immunohistochemical analysis of hMLH1 and hMSH2 proteins in serous ovarian tumours.

Abstract excerpt

Inactivation of DNA mismatch repair (MMR) genes is involved in carcinogenesis of sporadic and inherited human cancers. Mutations in MMR genes are associated with the loss of immunoexpression of hMLH1 and hMSH2 and may play a role in the mechanism of carcinogenesis of ovarian tumours. The aim of the study was to evaluate the immunoexpression of hMLH1 and hMSH2 in serous ovarian tumours. Sixty cases of benign,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adaptor Proteins, Signal Transducing
• Share to Gene Expression Regulation, Neoplastic