Article
Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels.
PLoS genetics - 1 Jan 2010
Igl Wilmar, Johansson Asa, Wilson James F, Wild Sarah H, Polasek Ozren, Hayward Caroline, Vitart Veronique, Hastie Nicholas, Rudan Pavao, Gnewuch Carsten, Schmitz Gerd, Meitinger Thomas, Pramstaller Peter P, Hicks Andrew A, Oostra Ben A, van Duijn Cornelia M, Rudan Igor, Wright Alan, Campbell Harry, Gyllensten Ulf
Abstract excerpt
Genome-wide association studies (GWAS) have identified 38 larger genetic regions affecting classical blood lipid levels without adjusting for important environmental influences. We modeled diet and physical activity in a GWAS in order to identify novel loci affecting total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels. The Swedish (SE) EUROSPAN cohort (N(SE) = 656) was screened for...
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