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Article

Genetic verification of Bordetella pertussis seed strains used for production of Japanese acellular pertussis vaccines.

Biologicals : journal of the International Association of Biological Standardization - 1 Mar 2010

Kamachi Kazunari, Fukuda Tadashi, Han Hyun-Ja, Toyoizumi-Ajisaka Hiromi, Mochida Keiko, Konda Toshifumi, Horiuchi Yoshinobu, Arakawa Yoshichika

Abstract excerpt

In Japan, the Bordetella pertussis strain Tohama provided by the National Institute of Health, Japan has been used for the production of acellular pertussis (aP) vaccines since 1981. In the present study, in order to verify the genetic consistency of B. pertussis vaccine seed strains, we analyzed the genetic properties of the working seeds obtained from five Japanese vaccine manufacturers, and compared them with...

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Identifiers

PMID: 20064727
DOI: 10.1016/j.biologicals.2009.10.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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