Article
Antigenic variation in Bordetella pertussis isolates recovered from adults and children in Japan.
Vaccine - 17 Mar 2008
Han Hyun-Ja, Kamachi Kazunari, Okada Kenji, Toyoizumi-Ajisaka Hiromi, Sasaki Yuko, Arakawa Yoshichika
Abstract excerpt
Recently, the incidence of reported pertussis cases of adults has dramatically increased in Japan. In the present study, we analyzed seven Bordetella pertussis isolates recovered from adults in Japan using pulsed-field gel electrophoresis (PFGE) and sequencing of their antigenic and virulence-associated proteins, compared with those from children. PFGE analysis demonstrated that the adult strains were closely...
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