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Article

Overcoming the hurdles in using mouse genetic models that block TGF-beta signaling.

Journal of immunological methods - 28 Feb 2010

Sanjabi Shomyseh, Flavell Richard A

Abstract excerpt

The recent recognition of the importance of transforming growth factor beta (TGF-beta) in mediating many cellular immune functions has popularized the use of mouse models where TGF-beta signaling is blocked in specific cell types. However, there are some caveats affiliated with each model. Here we describe and show evidence for some of the limitations of these models and provide insight into ways to improve the...

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Identifiers

PMID: 20060833
DOI: 10.1016/j.jim.2009.12.008
PMCID: PMC2845397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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