Article
A polymorphic mutation, c.-3279T>G, in the UGT1A1 promoter is a risk factor for neonatal jaundice in the Malay population.
Pediatric research - 1 Apr 2010
Yusoff Surini, Takeuchi Atsuko, Ashi Chitose, Tsukada Masako, Ma'amor Nur H, Zilfalil Bin A, Yusoff Narazah M, Nakamura Tsutomu, Hirai Midori, Harahap Indra S K, Gunadi, Lee Myeong J, Nishimura Noriyuki, Takaoka Yutaka, Morikawa Satoru, Morioka Ichiro, Yokoyama Naoki, Matsuo Masafumi, Nishio Hisahide, van Rostenberghe Hans
Abstract excerpt
The uridine diphosphoglucuronate-glucuronosyltransferase 1A1 (UGT1A1) gene encodes the enzyme responsible for bilirubin glucuronidation. To evaluate the contribution of UGT1A1 promoter mutations to neonatal jaundice, we determined the genotypes of c.-3279T>G, c.-3156G>A, and A(TA)7TAA in Malay infants with neonatal jaundice (patients) and in infants without neonatal jaundice (controls). In our population study,...
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