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Article

Polyploidy in Spitz Nevi: A Not Uncommon Karyotypic Abnormality Identifiable by Fluorescence in Situ Hybridization

20 Mar 2010

Abstract excerpt

Fluorescence in situ hybridization (FISH) often reveals imbalanced chromosomal gains in melanoma, whereas Spitz nevi typically have a normal complement of chromosomes. However, there may be a subset of Spitz nevi that are perfectly tetraploid by FISH analysis, and these cases may be confused diagnostically with melanoma. This study evaluates 41 cases of Spitz nevi that were histologically confirmed to be benign....

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PMID: 20051813
DOI: 10.1097/dad.0b013e3181b72d6f

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