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Article

A T-cell neoplasia showing clinicopathologic features of malignant histiocytosis with novel chromosomal abnormalities and N-ras mutation.

Cancer - 15 Apr 1991

Itoyama T, Sadamori N, Sasagawa I, Nakamura H, Tokunaga S, Yamada Y, Ichimaru M, Yoshida T, Kikuchi M, Takeshima F

Abstract excerpt

Malignant histiocytosis (MH) is a distinct disease entity defined clinically and morphologically. However, the neoplastic origin of MH is not well established. The authors report a 26-year-old woman who showed the typical clinicopathologic features of so-called MH. Cytogenetic and molecular genetic examinations were performed in addition to the morphologic and immunologic approach. The expression of CD2 and...

Topics

Adult
Bone Marrow
Chromosome Aberrations
Chromosome Disorders
DNA, Neoplasm
Female
Gene Amplification
Genes, ras
Histiocytic Sarcoma
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunophenotyping

Liver

Mutation

Transformation, Genetic

Source

Identifiers

PMID: 2004329
DOI: 10.1002/1097-0142(19910415)67:8<2103::aid-cncr2820670816>3.0.co;2-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2004329-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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