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Article

Malignant histiocytosis. A phenotypic and genotypic investigation.

The American journal of pathology - 1 May 1990

Cattoretti G, Villa A, Vezzoni P, Giardini R, Lombardi L, Rilke F

Abstract excerpt

Ten cases of malignant histiocytosis (MH) were evaluated for clinical and histopathologic features, phenotype, and rearrangement of T cell receptor (TCR) beta, gamma, and alpha and immunoglobulin (Ig) genes (7/10). All cases were HLA-DR+ and CD30-positive. Four cases had molecular evidence of T cell lineage such as TCR beta, gamma, and alpha rearrangements, and one additional case synthesized the cytoplasmic TCR...

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Identifiers

PMID: 2349962
PMCID: PMC1877429

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