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Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation

24 Dec 2009

Abstract excerpt

Clinical-grade human mesenchymal stromal cells (MSCs) have been expanded in vitro for tissue engineering or immunoregulatory purposes without standardized culture conditions or release criteria. Although human MSCs show poor susceptibility for oncogenic transformation, 2 recent studies described their capacity to accumulate chromosomal instability and to give rise to carcinoma in immunocompromised mice after...

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PMID: 20032501
DOI: 10.1182/blood-2009-05-219907

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