Article
Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival.
American journal of hematology - 1 Jan 2010
Han Xuesong, Zheng Tongzhang, Foss Francine M, Lan Qing, Holford Theodore R, Rothman Nathaniel, Ma Shuangge, Zhang Yawei
Abstract excerpt
Metabolic pathway enzymes, such as Cytochrome P450 (CYP), glutathione S-transferase (GST), and N-acetyltransferases (NAT) are involved in activation and detoxification of environmental carcinogens as well as drug metabolism. We hypothesized that the genetic variations in such metabolic pathways may affect NHL prognosis and survival. Follow-up information of 496 female NHL incident cases diagnosed during 1996-2000...
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