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Article

A Common Genetic Fingerprint in Leprosy and Crohn's Disease?

17 Dec 2009

Abstract excerpt

The cause-and-effect relationship between severe infections and death suggests that microbial pathogens are evolutionary sculptors of the genome. However, the genetic component of susceptibility to infections in the general population is complex and heterogeneous and is modulated by environmental factors such as determinants of microbial virulence. Thus, it is a challenge to identify specific genetic effects in...

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PMID: 20018963
DOI: 10.1056/nejme0910690

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