Article
Cryohydrocytosis: increased activity of cation carriers in red cells from a patient with a band 3 mutation.
Haematologica - 1 Feb 2010
Bogdanova Anna, Goede Jeroen S, Weiss Erwin, Bogdanov Nikolay, Bennekou Poul, Bernhardt Ingolf, Lutz Hans U
Abstract excerpt
BACKGROUND: Cryohydrocytosis is an inherited dominant hemolytic anemia characterized by mutations in a transmembrane segment of the anion exchanger (band 3 protein). Transfection experiments performed in Xenopus oocytes suggested that these mutations may convert the anion exchanger into a non-selective cation channel. The present study was performed to characterize so far unexplored ion transport pathways that...
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