Article
The Molecular Basis for Altered Cation Permeability in Hereditary Stomatocytic Human Red Blood Cells
16 Apr 2018
Abstract excerpt
Normal human RBCs have a very low basal permeability (leak) to cations, which is continuously corrected by the Na,K-ATPase. The leak is temperature-dependent, and this temperature dependence has been evaluated in the presence of inhibitors to exclude the activity of the Na,K-ATPase and NaK2Cl transporter. The severity of the RBC cation leak is altered in various conditions, most notably the hereditary...
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