Article
Exome sequencing of a multigenerational human pedigree.
PloS one - 14 Dec 2009
Hedges Dale J, Hedges Dale, Burges Dan, Powell Eric, Almonte Cherylyn, Huang Jia, Young Stuart, Boese Benjamin, Schmidt Mike, Pericak-Vance Margaret A, Martin Eden, Zhang Xinmin, Harkins Timothy T, Züchner Stephan
Abstract excerpt
Over the next few years, the efficient use of next-generation sequencing (NGS) in human genetics research will depend heavily upon the effective mechanisms for the selective enrichment of genomic regions of interest. Recently, comprehensive exome capture arrays have become available for targeting approximately 33 Mb or approximately 180,000 coding exons across the human genome. Selective genomic enrichment of the...
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