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Article

Targeted capture and massively parallel sequencing of 12 human exomes.

Nature - 10 Sept 2009

Ng Sarah B, Turner Emily H, Robertson Peggy D, Flygare Steven D, Bigham Abigail W, Lee Choli, Shaffer Tristan, Wong Michelle, Bhattacharjee Arindam, Eichler Evan E, Bamshad Michael, Nickerson Deborah A, Shendure Jay

Abstract excerpt

Genome-wide association studies suggest that common genetic variants explain only a modest fraction of heritable risk for common diseases, raising the question of whether rare variants account for a significant fraction of unexplained heritability. Although DNA sequencing costs have fallen marked...

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PMID: 19684571
DOI: 10.1038/nature08250
PMCID: PMC2844771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19684571-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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