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Article

KRAS mutation: comparison of testing methods and tissue sampling techniques in colon cancer.

The Journal of molecular diagnostics : JMD - 1 Jan 2010

Franklin Wilbur A, Haney Jerry, Sugita Michio, Bemis Lynne, Jimeno Antonio, Messersmith Wells A

Abstract excerpt

Treatment of colon carcinoma with the anti-epidermal growth factor receptor antibody Cetuximab is reported to be ineffective in KRAS-mutant tumors. Mutation testing techniques have therefore become an urgent concern. We have compared three methods for detecting KRAS mutations in 59 cases of colon carcinoma: 1) high resolution melting, 2) the amplification refractory mutation system using a bifunctional...

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Identifiers

PMID: 20007845
DOI: 10.2353/jmoldx.2010.080131
PMCID: PMC2797717

Genes

KRAS

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