Article
Combined iPLEX and TaqMan assays to screen for 45 common mutations in Lynch syndrome and FAP patients.
The Journal of molecular diagnostics : JMD - 1 Jan 2010
Dymerska Dagmara, Serrano-Fernández Pablo, Suchy Janina, Pławski Andrzej, Słomski Ryszard, Kaklewski Krzysztof, Scott Rodney J, Gronwald Jacek, Kładny Józef, Byrski Tomasz, Huzarski Tomasz, Lubiński Jan, Kurzawski Grzegorz
Abstract excerpt
Mutations of genes associated with the mismatch repair mechanism and mutations of the APC gene are the most frequent causes of hereditary colorectal cancer. An iPLEX test combined with TaqMan genotyping assays was therefore developed to identify common recurrent mutations of those genes in the Po...
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