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Article

JC Virus Mediates Invasion and Migration in Colorectal Metastasis

2 Dec 2009

Abstract excerpt

INTRODUCTION: JC Virus (JCV), a human polyomavirus, is frequently present in colorectal cancers (CRCs). JCV large T-Ag (T-Ag) expressed in approximately half of all CRC's, however, its functional role in CRC is poorly understood. We hypothesized that JCV T-Ag may mediate metastasis in CRC cells through increased migration and invasion. MATERIAL AND METHODS: CRC cell lines (HCT116 and SW837) were stably...

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PMID: 19997600
DOI: 10.1371/journal.pone.0008146

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