JC virus in the pathogenesis of colorectal cancer, an etiological agent or another component in a multistep process?

Abstract excerpt

JCV infection occurs early in childhood and last throughout life. JCV has been associated to colorectal cancer and might contribute to the cancer phenotype by several mechanisms. Among JCV proteins, particularly two of them, large T-antigen and agnoprotein, can interfere with cell cycle control and genomic instability mechanisms, but other viral proteins might also contribute to the process. Part of viral DNA...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Polyomavirus and related diseases
• Share to Viral-associated cancers and disorders
• Share to Virus-based gene therapy research