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Article

Secreted subtilisin Sub3 from <i>Microsporum canis</i> is required for adherence to but not for invasion of the epidermis

28 Nov 2009

Abstract excerpt

BACKGROUND: Microsporum canis is a pathogenic dermatophyte that causes a superficial cutaneous mycosis, mainly in cats and humans. Proteolytic enzymes, including subtilisins, have been postulated to be key factors involved in adherence and invasion of the stratum corneum and keratinized epidermal structures. OBJECTIVES: To evaluate the importance of Sub3 as a M. canis virulence factor using a SUB3 RNA-silenced...

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Identifiers

PMID: 19995373
DOI: 10.1111/j.1365-2133.2009.09608.x

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