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Article

Occurrence of species of low-density lipoprotein with defective clearance in patients with primary moderate hypercholesterolaemia.

Journal of internal medicine - 1 Nov 1992

Vega G L, Grundy S M

Abstract excerpt

Recent studies have shown that one cause of primary moderate hypercholesterolaemia is familial defective apolipoprotein B-100 (FDB), a condition in which a mutation in apolipoprotein B-100 (apo B-100) causes low-density lipoproteins (LDL) to bind poorly to LDL receptors. One specific mutation, a glutamine-for-arginine transformation at position 3500 of apo B-100, has been reported to produce FDB. However, other...

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Source

Identifiers

PMID: 1453124
DOI: 10.1111/j.1365-2796.1992.tb00606.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Occurrence of species of low-density lipoprotein with defective clearance in patients with primary moderate hypercholesterolaemia.PMID 1453124Read ↗

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Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.Semantic proximity Read ↗

Mutation in apolipoprotein B associated with hypobetalipoproteinemia despite decreased binding to the low density lipoprotein receptor.Semantic proximity Read ↗

The affinity of low-density lipoproteins and of very-low-density lipoprotein remnants for the low-density lipoprotein receptor in homozygous familial defective apolipoprotein B-100.Semantic proximity Read ↗

Isolation of allele-specific, receptor-binding-defective low density lipoproteins from familial defective apolipoprotein B-100 subjects.Semantic proximity Read ↗

Mutations in the apolipoprotein (apo) B-100 receptor-binding region: detection of apo B-100 (Arg3500-->Trp) associated with two new haplotypes and evidence that apo B-100 (Glu3405-->Gln) diminishes receptor-mediated uptake of LDL.Semantic proximity Read ↗

Detection of familial defective apolipoprotein B-100 among patients clinically diagnosed with heterozygous familial hypercholesterolemia in maritime Canada.Semantic proximity Read ↗

Familial defective apolipoprotein B-100. Comparison with familial hypercholesterolemia in 18 cases detected in Munich.Semantic proximity Read ↗

Clinical signs of familial hypercholesterolemia in patients with familial defective apolipoprotein B-100 and normal low density lipoprotein receptor function.Semantic proximity Read ↗

ApoB-75, a truncation of apolipoprotein B associated with familial hypobetalipoproteinemia: genetic and kinetic studies.Semantic proximity Read ↗

Decreased resistance against in vitro oxidation of LDL from patients with familial defective apolipoprotein B-100.Semantic proximity Read ↗

Lipoprotein(a) in subjects with familial defective apolipoprotein B100.Semantic proximity Read ↗

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