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Article

Antithrombin Vicenza, Ala 384 to Pro (GCA to CCA) mutation, transforming the inhibitor into a substrate.

British journal of haematology - 1 Jan 1991

Caso R, Lane D A, Thompson E A, Olds R J, Thein S L, Panico M, Blench I, Morris H R, Freyssinet J M, Aiach M

Abstract excerpt

Antithrombin (AT) Vicenza has been previously identified as a functionally abnormal antithrombin associated with familial thrombosis (Finazzi et al, 1985). It binds normally to heparin, but loses its affinity following interaction with thrombin: it is a poor inhibitor of thrombin. AT Vicenza was isolated from plasma by heparin-Sepharose and thrombin-Sepharose chromatography, fragmented with cyanogen bromide...

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Source

Identifiers

PMID: 1998601
DOI: 10.1111/j.1365-2141.1991.tb07953.x

Genes

GCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antithrombin Vicenza, Ala 384 to Pro (GCA to CCA) mutation, transforming the inhibitor into a substrate.PMID 1998601Read ↗

Antithrombin Glasgow II: alanine 382 to threonine mutation in the serpin P12 position, resulting in a substrate reaction with thrombin.Semantic proximity Read ↗

Symptomatic type II protein C deficiency caused by a missense mutation (Gly 381-->Ser) in the substrate-binding pocket.Semantic proximity Read ↗

Familial variant of antithrombin III (AT III Bligny, 47Arg to His) associated with protein C deficiency.Semantic proximity Read ↗

Antithrombin Cambridge II, 384 Ala to Ser. Further evidence of the role of the reactive centre loop in the inhibitory function of the serpins.Semantic proximity Read ↗

Genetic analysis and functional characterization of prothrombins Corpus Christi (Arg382-Cys), Dhahran (Arg271-His), and hypoprothrombinemia.Semantic proximity Read ↗

A novel dysfunctional protein C (protein C Padua 2) associated with a thrombotic tendency: substitution of Cys for Arg-1 results in a strongly reduced affinity for binding of Ca++.Semantic proximity Read ↗

Antithrombin Budapest 3. An antithrombin variant with reduced heparin affinity resulting from the substitution L99F.Semantic proximity Read ↗

Antithrombin Padua. I: Impaired heparin binding caused by an Arg47 to his (CGT to CAT) substitution.Semantic proximity Read ↗

A congenitally abnormal fibrinogen (Vlissingen) with a 6-base deletion in the gamma-chain gene, causing defective calcium binding and impaired fibrin polymerization.Semantic proximity Read ↗

Important role of arginine 129 in heparin-binding site of antithrombin III. Identification of a novel mutation arginine 129 to glutamine.Semantic proximity Read ↗

Clinical and biochemical characterization of antithrombin III Franconville, a variant with Pro 41 Leu mutation.Semantic proximity Read ↗

Antithrombin 'DREUX' (Lys 114Glu): a variant with complete loss of heparin affinity.Semantic proximity Read ↗

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