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Article

Antithrombin Budapest 3. An antithrombin variant with reduced heparin affinity resulting from the substitution L99F.

FEBS letters - 6 Apr 1992

Olds R J, Lane D A, Boisclair M, Sas G, Bock S C, Thein S L

Abstract excerpt

The molecular basis and functional properties of a variant antithrombin (AT) protein. AT Budapest 3, were studied. A single base substitution was identified in codon 99, CTC----TTC, altering the normal leucine to phenylalanine. The proband presented with a history of venous thrombotic disease and was found to be homozygous for the mutation. The variant protein demonstrated reduced heparin affinity and reduced...

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Source

Identifiers

PMID: 1555650
DOI: 10.1016/0014-5793(92)80854-a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antithrombin Budapest 3. An antithrombin variant with reduced heparin affinity resulting from the substitution L99F.PMID 1555650Read ↗

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How we treat severe inherited antithrombin deficiency: lessons from cases homozygous for the Budapest 3 variant.Semantic proximity Read ↗

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