Article
Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor 1alpha.
Bioscience, biotechnology, and biochemistry - 1 Dec 2009
Yanaka Noriyuki, Kaseda Yurika, Tanaka Anna, Nogusa Yoshihito, Sumiyoshi Naoki, Kato Norihisa
Abstract excerpt
Zinc finger protein ZPR1 (ZPR1) binds to eukaryotic translation elongation factor 1alpha (eEF1alpha) in response to growth stimuli, and is also involved in transcription and cell cycle regulation. In this study, we characterized the interaction of ZPR1 and eEF1alpha and generated a ZPR1 mutant that constitutively interacted with eEF1alpha. ZPR1-DeltaA (Delta193-246) bound to eEF1alpha independently of Zn(2+) in...
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