Article
Heterozygous orthodenticle homeobox 2 mutations are associated with variable pituitary phenotype.
The Journal of clinical endocrinology and metabolism - 1 Feb 2010
Dateki Sumito, Kosaka Kitaro, Hasegawa Kosei, Tanaka Hiroyuki, Azuma Noriyuki, Yokoya Susumu, Muroya Koji, Adachi Masanori, Tajima Toshihiro, Motomura Katsuaki, Kinoshita Eiichi, Moriuchi Hiroyuki, Sato Naoko, Fukami Maki, Ogata Tsutomu
Abstract excerpt
CONTEXT: Although recent studies have suggested a positive role of OTX2 in pituitary as well as ocular development and function, detailed pituitary phenotypes in OTX2 mutations and OTX2 target genes for pituitary function other than HESX1 and POU1F1 remain to be determined. OBJECTIVE: We aimed to examine such unresolved issues. SUBJECTS: We studied 94 Japanese patients with various ocular or pituitary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.