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Article

Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein

29 Jul 2011

Abstract excerpt

OBJECTIVE: Cholesteryl ester transfer protein (CETP) plays a central role in the metabolism of high-density lipoprotein particles. Therefore, we searched for new drugs that bind to CETP and modulate its activity. METHODS: A preliminary pharmacophore-based parallel screening approach indicated that leoligin, a major lignan of Edelweiss (Leontopodium alpinum Cass.), might bind to CETP. Therefore we incubated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21820657
DOI: 10.1016/j.atherosclerosis.2011.07.023

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