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Article

Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition.

Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 2009

Lower Karen M, Hughes Jim R, De Gobbi Marco, Henderson Shirley, Viprakasit Vip, Fisher Chris, Goriely Anne, Ayyub Helena, Sloane-Stanley Jackie, Vernimmen Douglas, Langford Cordelia, Garrick David, Gibbons Richard J, Higgs Douglas R

Abstract excerpt

It is well established that all of the cis-acting sequences required for fully regulated human alpha-globin expression are contained within a region of approximately 120 kb of conserved synteny. Here, we show that activation of this cluster in erythroid cells dramatically affects expression of ap...

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Share to alpha-Globins
Share to Chromosomes, Human, Pair 16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Regulatory Sequences, Nucleic Acid

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Source

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Identifiers

PMID: 19959666
DOI: 10.1073/pnas.0909331106
PMCID: PMC2799829

Genes

NME4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19959666-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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