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Article

Quantification of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specific evaluation of the metabolic ratio as biomarker of CYP3A activity.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 1 Jan 2010

Lutz Ursula, Bittner Nataly, Ufer Mike, Lutz Werner K

Abstract excerpt

Drug-drug and food-drug interactions are often due to an inhibition or induction of drug-metabolizing cytochrome P450 (CYP) enzymes and may result in non-response or adverse reactions. Hence, phenotypic biomarkers of CYP activity appear as useful tools for individualized pharmacotherapy. The metabolic ratio (MR) of the concentration of 6beta-hydroxycortisol (6beta-OHC) to cortisol (MR 6beta-OHC/cortisol) in human...

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Share to Chromatography, Liquid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hydrocortisone

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Identifiers

PMID: 19959402
DOI: 10.1016/j.jchromb.2009.11.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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