Article
Microsomal enzyme induction and clinical aggravation of porphyria: the evaluation of human urinary 6beta-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 activity.
Journal of clinical pharmacology - 1 Dec 2002
Uejima Etsuko, Takahashi Kyoko, Morisaki Tomoko, Takahashi Koichi, Ohno Masako, Nishida Yuko, Moriya Masayuki, Kaido Misako, Abe Kazuo, Sakoda Saburo, Yanagihara Takehiko, Kurokawa Nobuo, Azuma Junichi
Abstract excerpt
The clinical aspect of porphyria has been investigated, and it is well known that porphyrinogens such as estrogens and alcohol or other inducers of P450 isoenzymes exacerbate the porphyric state. However, there can be a delay in diagnosing porphyria and a difficulty in selecting safe medicine for...
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