Article
Intraindividual and interindividual variabilities in endogenous cortisol 6β-hydroxylation clearance as an index for in vivo CYP3A phenotyping in humans.
Drug metabolism and disposition: the biological fate of chemicals - 1 Feb 2013
Shibasaki Hiromi, Hosoda Kaori, Goto Mari, Suzuki Atsushi, Yokokawa Akitomo, Ishii Kazuo, Furuta Takashi
Abstract excerpt
This study was designed to evaluate the in vivo activity of cytochrome P450 3A (CYP3A) in 49 healthy Japanese subjects aged 22-58 years using endogenous cortisol 6β-hydroxylation clearance [CLm(6β)], a novel biomarker for CYP3A phenotyping. CLm(6β) in the 49 healthy subjects was 2.40 ± 0.79 ml/min with an approximately 4-fold interindividual variability of CYP3A activity. The mean clearance in the 24 women was...
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