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Article

Candidate gene analysis of semaphorins in patients with Alzheimer's disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Apr 2010

Villa Chiara, Venturelli Eliana, Fenoglio Chiara, De Riz Milena, Scalabrini Diego, Cortini Francesca, Serpente Maria, Cantoni Claudia, Bresolin Nereo, Scarpini Elio, Galimberti Daniela

Abstract excerpt

Semaphorins of the SemaIV family are expressed in neurons and decreased in brains from patients with Alzheimer's disease (AD). Accumulation of an internalized form of Sema3A is associated with degeneration of neurons, making these molecules candidates for the development of AD. Single nucleotide polymorphisms (SNPs) rs36026860 and rs28469467 in Sema3A as well as rs13284404 and rs11526468 in Sema4D were analyzed...

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PMID: 19957197
DOI: 10.1007/s10072-009-0200-1

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