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Article

Altered synthesis of cartilage-specific proteoglycans by mutant human cartilage oligomeric matrix protein.

Clinics in orthopedic surgery - 1 Dec 2009

Kwak Yoon Hae, Roh Jae Young, Lee Ki Seok, Park Hui Wan, Kim Hyun Woo

Abstract excerpt

BACKGROUND: The mechanism by which mutant cartilage oligomeric matrix protein (COMP) induces a pseudoachondroplasia phenotype remains unknown, and the reason why a mutation of a minor protein of the growth plate cartilage causes total disruption of endochondral bone formation has not yet been det...

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Source

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Identifiers

PMID: 19956474
DOI: 10.4055/cios.2009.1.4.181
PMCID: PMC2784957

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19956474-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Altered synthesis of cartilage-specific proteoglycans by mutant human cartilage oligomeric matrix protein.PMID 19956474Read ↗

Expression of mutant cartilage oligomeric matrix protein in human chondrocytes induces the pseudoachondroplasia phenotype.Semantic proximity Read ↗

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A secreted variant of cartilage oligomeric matrix protein carrying a chondrodysplasia-causing mutation (p.H587R) disrupts collagen fibrillogenesis.Semantic proximity Read ↗

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Antisense Reduction of Mutant COMP Reduces Growth Plate Chondrocyte Pathology.Semantic proximity Read ↗

Health consequences of mutant cartilage oligomeric matrix protein and its relationship to abnormal growth and joint degeneration.Semantic proximity Read ↗

COMP mutations, chondrocyte function and cartilage matrix.Semantic proximity Read ↗

Disruption of extracellular matrix structure may cause pseudoachondroplasia phenotypes in the absence of impaired cartilage oligomeric matrix protein secretion.Semantic proximity Read ↗

Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudoachondroplasia musculoskeletal tissues.Semantic proximity Read ↗

Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways.Semantic proximity Read ↗

Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathwaysSemantic proximity Read ↗

COMP mutations: domain-dependent relationship between abnormal chondrocyte trafficking and clinical PSACH and MED phenotypes.Semantic proximity Read ↗

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