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Article

Altered synthesis of cartilage-specific proteoglycans by mutant human cartilage oligomeric matrix protein.

Clinics in orthopedic surgery - 1 Dec 2009

Kwak Yoon Hae, Roh Jae Young, Lee Ki Seok, Park Hui Wan, Kim Hyun Woo

Abstract excerpt

BACKGROUND: The mechanism by which mutant cartilage oligomeric matrix protein (COMP) induces a pseudoachondroplasia phenotype remains unknown, and the reason why a mutation of a minor protein of the growth plate cartilage causes total disruption of endochondral bone formation has not yet been determined. The current study was performed to investigate the effects of mutated COMP on the synthesis of the...

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Source

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Identifiers

PMID: 19956474
DOI: 10.4055/cios.2009.1.4.181
PMCID: PMC2784957

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Altered synthesis of cartilage-specific proteoglycans by mutant human cartilage oligomeric matrix protein.PMID 19956474Read ↗

Expression of mutant cartilage oligomeric matrix protein in human chondrocytes induces the pseudoachondroplasia phenotype.Semantic proximity Read ↗

Transgenic mice expressing D469Delta mutated cartilage oligomeric matrix protein (COMP) show growth plate abnormalities and sternal malformations.Semantic proximity Read ↗

A secreted variant of cartilage oligomeric matrix protein carrying a chondrodysplasia-causing mutation (p.H587R) disrupts collagen fibrillogenesis.Semantic proximity Read ↗

Secretion of cartilage oligomeric matrix protein is affected by the signal peptide.Semantic proximity Read ↗

Antisense Reduction of Mutant COMP Reduces Growth Plate Chondrocyte Pathology.Semantic proximity Read ↗

Health consequences of mutant cartilage oligomeric matrix protein and its relationship to abnormal growth and joint degeneration.Semantic proximity Read ↗

COMP mutations, chondrocyte function and cartilage matrix.Semantic proximity Read ↗

Disruption of extracellular matrix structure may cause pseudoachondroplasia phenotypes in the absence of impaired cartilage oligomeric matrix protein secretion.Semantic proximity Read ↗

Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudoachondroplasia musculoskeletal tissues.Semantic proximity Read ↗

Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways.Semantic proximity Read ↗

Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathwaysSemantic proximity Read ↗

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