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Article

Tandem repeats modify the structure of human genes hosted in segmental duplications.

Genome biology - 1 Jan 2009

De Grassi Anna, Ciccarelli Francesca D

Abstract excerpt

BACKGROUND: Recently duplicated genes are often subject to genomic rearrangements that can lead to the development of novel gene structures. Here we specifically investigated the effect of variations in internal tandem repeats (ITRs) on the gene structure of human paralogs located in segmental duplications. RESULTS: We found that around 7% of the primate-specific genes located within duplicated regions of the...

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Identifiers

PMID: 19954527
DOI: 10.1186/gb-2009-10-12-r137
PMCID: PMC2812944

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