Article
An Alu transposition model for the origin and expansion of human segmental duplications.
American journal of human genetics - 1 Oct 2003
Bailey Jeffrey A, Liu Ge, Eichler Evan E
Abstract excerpt
Relative to genomes of other sequenced organisms, the human genome appears particularly enriched for large, highly homologous segmental duplications (> or =90% sequence identity and > or =10 kbp in length). The molecular basis for this enrichment is unknown. We sought to gain insight into the mechanism of origin, by systematically examining sequence features at the junctions of duplications. We analyzed 9,464...
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