Analysis of granulocyte-macrophage colony-stimulating factor action in differentiating myeloid leukemia cells: treatment with DMSO may reveal a common pathway for growth factor gene regulation.

Abstract excerpt

Previous studies showed that factor-independent, late-passage HL60 acute nonlymphocytic leukemia (ANLL) cells proliferated in response to granulocyte-macrophage colony-stimulating factor (GM-CSF) after treatment with dimethylsulfoxide (DMSO) or other agents inducing cellular differentiation. In the present studies, we examined mechanisms of this response. After treatment with DMSO, GM-CSF delayed expression of...

Topics

• Blotting, Northern
• Cell Differentiation
• Cell Line
• Dactinomycin
• Dimethyl Sulfoxide
• Epidermal Growth Factor
• ErbB Receptors
• Gene Expression Regulation, Leukemic
• Genes, myc
• Granulocyte-Macrophage Colony-Stimulating Factor