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Article

Natural selection coupled with intragenic recombination shapes diversity patterns in the major histocompatibility complex class II genes of the giant panda.

Journal of experimental zoology. Part B, Molecular and developmental evolution - 15 May 2010

Chen Yi-Yan, Zhang Ying-Ying, Zhang He-Min, Ge Yun-Fa, Wan Qiu-Hong, Fang Sheng-Guo

Abstract excerpt

Ample variations of the major histocompatibility complex (MHC) genes are essential for vertebrates to adapt to various environmental conditions. In this study, we investigated the genetic variations and evolutionary patterns of seven functional MHC class II genes (one DRA, two DRB, two DQA, and two DQB) of the giant panda. The results showed the presence of two monomorphic loci (DRA and DQB2) and five polymorphic...

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Gene Frequency
Genes, MHC Class II
Heterozygote
Recombination, Genetic
Selection, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Alignment

Species Specificity

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PMID: 19950128
DOI: 10.1002/jez.b.21327

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