Article
Minimal residual disease and normalization of the bone marrow after long-term treatment with alpha-interferon2b in polycythemia vera. A report on molecular response patterns in seven patients in sustained complete hematological remission.
Hematology (Amsterdam, Netherlands) - 1 Dec 2009
Larsen Thomas Stauffer, Møller Michael Boe, de Stricker Karin, Nørgaard Peter, Samuelsson Jan, Marcher Claus, Andersen Morten T, Bjerrum Ole Weis, Hasselbalch Hans Carl
Abstract excerpt
Polycythemia vera (PV) is characterized by the presence of the JAK2V617F mutation in virtually all patients. Several studies have shown that the JAK2V617F mutational load decreases during treatment with alpha-interferon 2. We report on molecular and histomorphological bone marrow responses in seven PV patients with profound molecular responses during and after long-term treatment with alpha-interferon 2b. All...
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