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Article

Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior.

The Journal of biological chemistry - 5 Feb 2010

Mashanov Gregory I, Nobles Muriel, Harmer Stephen C, Molloy Justin E, Tinker Andrew

Abstract excerpt

We have directly observed the trafficking and fusion of ion channel containing vesicles and monitored the release of individual ion channels at the plasma membrane of live mammalian cells using total internal reflection fluorescence microscopy. Proteins were fused in-frame with green or red fluorescent proteins and expressed at low level in HL-1 and HEK293 cells. Dual color imaging revealed that vesicle...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19940153
DOI: 10.1074/jbc.M109.039974
PMCID: PMC2823507

Genes

KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior.PMID 19940153Read ↗

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The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking.Semantic proximity Read ↗

Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.Semantic proximity Read ↗

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