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Biosynthesis of polylactic acid and its copolymers using evolved propionate CoA transferase and PHA synthase.

Biotechnology and bioengineering - 1 Jan 2010

Yang Taek Ho, Kim Tae Wan, Kang Hye Ok, Lee Sang-Hyun, Lee Eun Jeong, Lim Sung-Chul, Oh Sun Ok, Song Ae-Jin, Park Si Jae, Lee Sang Yup

Abstract excerpt

For the synthesis of polylactic acid (PLA) and its copolymers by one-step fermentation process, heterologous pathways involving Clostridium propionicum propionate CoA transferase (Pct(Cp)) and Pseudomonas sp. MBEL 6-19 polyhydroxyalkanoate (PHA) synthase 1 (PhaC1(Ps6-19)) were introduced into Escherichia coli for the generation of lactyl-CoA endogenously and incorporation of lactyl-CoA into the polymer,...

Topics

Acyltransferases
Blotting, Western
Clostridium
Coenzyme A-Transferases
Escherichia coli
Lactic Acid
Molecular Structure
Mutation
Polyesters
Polymers
Recombinant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

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PMID: 19937726
DOI: 10.1002/bit.22547

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