Article
Molecular analysis of variant plasmid forms of a bivalent Salmonella typhi-Shigella sonnei vaccine strain.
Journal of clinical microbiology - 1 Jan 1991
Hartman A B, Ruiz M M, Schultz C L
Abstract excerpt
The Salmonella typhi-Shigella sonnei hybrid vaccine strain 5076-IC was constructed to express the S. sonnei form I antigen, which may play an important role in producing protective immunity. Three clonal variants which existed in preparations of the vaccine could be distinguished phenotypically by lactose utilization, S. sonnei form I antigen expression, and restriction enzyme analysis of large plasmid DNA. Since...
Topics
- Antigens, Bacterial
- Bacterial Vaccines
- DNA Probes
- DNA, Bacterial
- Genetic Variation
- Humans
- Lac Operon
- Plasmids
- Salmonella typhi
- Shigella sonnei
- Vaccines, Synthetic