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Article

Factor H in Porcine Seminal Plasma Protects Sperm against Complement Attack in Genital Tracts

17 Nov 2009

Abstract excerpt

We found that factor H (FH) exists in porcine seminal plasma. Purified FH strongly inhibited serum alternative pathway complement activation against lipopolysaccharide. The molecular weight, pI, and heparin-binding activity of the purified protein were different from those of purified FH from porcine serum. The complement regulatory activity of seminal plasma FH was approximately 2-fold stronger than that of...

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PMID: 19920146
DOI: 10.1074/jbc.m109.063495

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