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Article

Human Sperm Binding Is Mediated by the Sialyl-Lewis <sup>x</sup> Oligosaccharide on the Zona Pellucida

19 Aug 2011

Abstract excerpt

Human fertilization begins when spermatozoa bind to the extracellular matrix coating of the oocyte, known as the zona pellucida (ZP). One spermatozoan then penetrates this matrix and fuses with the egg cell, generating a zygote. Although carbohydrate sequences on the ZP have been implicated in sperm binding, the nature of the ligand was unknown. Here, ultrasensitive mass spectrometric analyses revealed that the...

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PMID: 21852454
DOI: 10.1126/science.1207438

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