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Article

Targeted and restricted complement activation on acrosome-reacted spermatozoa

21 Apr 2005

Abstract excerpt

A specific hypoglycosylated isoform of the complement regulator membrane cofactor protein (MCP; CD46) is expressed on the inner acrosomal membrane (IAM) of spermatozoa. This membrane is exposed after the acrosome reaction, an exocytosis event that occurs upon contact with the zona pellucida. We initiated this investigation to assess MCP's regulatory function in situ on spermatozoa. Upon exposure of human...

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PMID: 15849610
DOI: 10.1172/jci23213

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